Acanthamoeba keratitis: an increasingly common infectious disease of the cornea

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Keratitis: An Inflammation of Cornea

Keratitis is an inflammation of the cornea, which has both infectious and non-infectious etiology, among which infectious is more common. Non-infective keratitis may be caused by minor injuries, prolong contact lens usage, hypersensitivity responses, atopic conditions or some autoimmune disorders. Infective keratitis is an infection of the cornea, caused by either bacteria, fungus, virus or pro...

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[Acanthamoeba keratitis].

Three patients, women aged 69, 25 and 30 years, with refractory keratitis were found to have a rare infection with Acanthamoeba. All wore soft contact lenses. The frequency of Acanthamoeba keratitis increased in recent years. At present, an efficacious antiprotozoal therapy is available, for instance in the form of polyhexamethylene biguanide and propamidine. In cases of refractory keratitis, t...

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Persistence of acanthamoeba antigen following acanthamoeba keratitis.

AIM To investigate the hypothesis that persistent corneal and scleral inflammation following acanthamoeba keratitis is not always caused by active amoebic infection but can be due to persisting acanthamoebic antigens METHODS 24 lamellar corneal biopsy and penetrating keratoplasty specimens were obtained from 14 consecutive patients at various stages of their disease and divided for microscopy...

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Laboratory investigation of Acanthamoeba keratitis.

Following the diagnosis of Acanthamoeba keratitis in a contact lens wearer, the antimicrobial susceptibility of the clinical isolate and the environmental source of the infection were investigated. Contrary to previous reports, in vitro antimicrobial testing showed that the infecting strain was inherently resistant to propamidine isethionate. Restriction endonuclease digestion analysis of Acant...

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Acanthamoeba keratitis--importance of the early diagnosis.

This is a case report of Acanthamoeba as a causative agent of keratitis at the Department of Ophthalmology, University Hospital Rijeka. Delay in treatment led to an advanced stage of the disease with multiple complications. Initially, presented symptoms were similar to those of herpetic keratitis. In the mean time progression of the disease led to a cloudy cornea with a stromal ring infiltrate,...

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ژورنال

عنوان ژورنال: The Lancet Microbe

سال: 2021

ISSN: 2666-5247

DOI: 10.1016/s2666-5247(21)00093-8